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Table of Contents

Vitamin D: Benefits, Sources, Deficiency, and Toxicity

What is Vitamin D?

Vitamin D, also called cholecalciferol, is a fat-soluble vitamin that acts as both a nutrient and a hormone. It plays a critical role in calcium and phosphorus absorption, helping the body regulate bone growth and maintain strong bones.

Unlike other vitamins, Vitamin D can be synthesised in the skin when exposed to sunlight. It is also found in some foods and supplements. Its functions extend beyond bone health — Vitamin D supports neuromuscular activity, immune function, cell growth regulation, and defence against infections.

Vitamin D Synthesis and Metabolism

The process of Vitamin D production starts with 7-dehydrocholesterol, a cholesterol derivative in the skin. When exposed to UVB sunlight, it is converted to provitamin D and then to Vitamin D.

For Vitamin D to become biologically active, it undergoes two hydroxylation steps:

In the liver, it converts to 25-hydroxyvitamin D (calcidiol).

In the kidneys, it becomes 1,25-dihydroxyvitamin D (calcitriol) — the active form.

Some tissues, like the breast, prostate, and colon, can also perform this conversion, though at lower levels.

Functions of Vitamin D in the Body

Vitamin D is essential for several body processes:

Bone Health: Maintains calcium and phosphate balance, prevents rickets in children and osteomalacia in adults.

Prevents Hypocalcemia Tetany: Reduces muscle spasms and cramps.
Bone Remodeling: Supports osteoblasts and osteoclasts in bone formation.
Prevents Osteoporosis: Especially in older adults.

Reduces Inflammation: Helps modulate immune and cell growth processes.
Neuromuscular Activity & Glucose Metabolism: Aids in nerve function and blood sugar regulation.

Sources of Vitamin D

1. Sunlight Exposure

The primary source of Vitamin D is sunlight. However, many factors affect Vitamin D synthesis:

Season and time of day
Cloud cover and smog

Skin tone (darker skin requires more sun exposure)
Sunscreen use
UVB rays do not pass through glass

Experts suggest 5–30 minutes of sun exposure, 2–3 times a week, between 10 AM and 3 PM on the face, arms, or legs for adequate Vitamin D.

2. Food Sources of Vitamin D

Although limited, Vitamin D is naturally present in some foods and fortified products, such as:

Fatty fish (salmon, sardines, mackerel, tuna, herring)
Cod liver oil

Egg yolks
Beef liver
Fortified milk, soy milk, and orange juice

Fortified cereals
Soft margarine

3. Vitamin D Supplements

For people with limited sun exposure or dietary restrictions, supplements provide an easy solution.

Commonly available in 1000 IU doses (tablets, capsules, or liquids).
Should be taken under medical guidance, especially at doses higher than 4000 IU daily.

Vitamin D Deficiency

Symptoms of Deficiency

Bone discomfort (lower back, pelvis, legs)

Muscle weakness or aches
Falls and impaired physical function
Low back pain (especially in women)

High-Risk Groups

People with inflammatory bowel disease (Crohn’s, ulcerative colitis)
Individuals with obesity (Vitamin D stored in fat but unavailable)
Elderly people with reduced skin synthesis

People who had gastric bypass surgery
Vegans or those with lactose intolerance

Conditions from Prolonged Deficiency

Rickets – soft, deformed bones in children

Osteomalacia – weak, soft bones in adults (reversible with supplements)
Osteoporosis – brittle bones in older adults

Vitamin D Toxicity

Toxicity is rare and usually caused by excessive supplement use, not sun or food intake.

Symptoms of Vitamin D Toxicity

Weight loss and appetite loss
Irregular heartbeat

High blood calcium (hypercalcemia), leading to hardened blood vessels and kidney damage

👉 Always consult a doctor before taking high-dose Vitamin D supplements.

Conclusion

Vitamin D is essential for skeletal health and plays a role in immune support, inflammation reduction, and muscle function. While sunlight remains the best source, many people still experience a deficiency due to lifestyle and environmental factors.

To maintain healthy Vitamin D levels:

Get moderate sunlight exposure
Eat Vitamin D-rich and fortified foods

Consider supplements if recommended by a healthcare professional

Further research is ongoing to understand Vitamin D’s role in non-skeletal diseases like cancer, diabetes, and autoimmune disorders.

Frequently Asked Questions (FAQ)

1. How much Vitamin D do I need daily?
The recommended daily allowance (RDA) for most adults is 600–800 IU. Older adults may need more.

2. Can I get enough Vitamin D from sunlight alone?
Yes, but it depends on factors like skin type, location, and time of year. Some people may still require supplements.

3. Can too much Vitamin D be harmful?
Yes. Excessive supplementation can cause toxicity with dangerous calcium buildup. Always consult a doctor.

4. Which foods are richest in Vitamin D?
Fatty fish, cod liver oil, fortified milk, orange juice, cereals, egg yolks, and beef liver.

5. Who is most at risk of Vitamin D deficiency?
Elderly people, individuals with dark skin, those with limited sun exposure, vegans, and patients with certain medical conditions.

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CHOLECALCIFEROL VITAMIN D AND AGEING

Vitamin D: Benefits, Sources, Deficiency, and Toxicity

What is Vitamin D?

Vitamin D Synthesis and Metabolism

Functions of Vitamin D in the Body